Fenteany, G., Gaur, P., Sharma, G., Pintér, L., Kiss, E. & Haracska, L. Robust high-throughput assays to assess discrete steps in ubiquitination and related cascades. BMC Mol. Cell Biol. 21, 21 (2020).
Fenteany, G., Gaur, P., Hegedűs, L., Dudás, K., Kiss, E., Wéber, E., Hackler, L., Martinek, T., Puskás, L.G. & Haracska, L. Multilevel structure–activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism. Sci. Rep. 9, 12801 (2019).
Fenteany, G.; Inoue, T.; Bahtiyar, G.; Sacerdote, A. Association of vitamin D repletion with normalization of elevated serum 17-OH progesterone. J. Med. Case Rep. 2017, 3, 29.
Powell, D.; Inoue, T.; Bahtiyar, G.; Fenteany, G; Sacerdote, A. Treatment of nonclassic 11-hydroxylase deficiency with Ashwagandha root. Case Rep. Endocrinol. 2017, 2017, Article ID 1869560. [HTML]
Magpusao, A.N.; Omolloh, G.; Johnson, J.; Gascón, J.; Peczuh, M.W.; Fenteany, G. Cardiac glycoside activities link Na(+)/K(+) ATPase ion-transport to breast cancer cell migration via correlative SAR. ACS Chem. Biol. 2012, 10, 561-569. [Abstract] [HTML] [PDF]
Eddy, N.A.; Richardson, J.J.; Fenteany, G. The effect of Lewis acids on the cycloaddition of 3,3,6-trimethylcyclohex-5-ene-1,2,4-trione: hydrogen transfer versus cycloaddition with cyclopentadiene. Eur. J. Org. Chem. 2013, 2013(23), 5041-5044. [Abstract] [HTML] [PDF]
Clark, A.G.; Sider, J.R.; Verbrugghe, K.; Fenteany, G.; von Dassow, G.; Bement, W.M. Identification of small molecule inhibitors of cytokinesis and single cell wound repair. Cytoskeleton 2012, 69, 1010-1020. [Abstract] [HTML] [PDF]
Rudnitskaya, A.N.; Eddy, N.A.; Fenteany, G.; Gascón, J.A. Recognition and reactivity in the binding between Raf kinase inhibitor protein and its small-molecule inhibitor locostatin. J. Phys. Chem. B. 2012, 116, 10176-10181. [Abstract] [HTML] [PDF]
Ren, G.; Baritaki, S.; Marathe, H.; Feng, J.; Park, S.; Beach, S.; Bazeley, P.S.; Beshir, A.B.; Fenteany, G.; Mehra, R.; Daignault, S.; Al Mulla, F.; Keller, E.; Bonavida, B.; de la Serna, I.; Yeung, K.C. Polycomb protein EZH2 regulates tumor invasion via the transcriptional repression of the metastasis suppressor RKIP in breast and prostate cancer. Cancer. Res. 2012, 72, 3091-3104. [Abstract] [HTML] [PDF]
Eddy, N.A.; Kelly, C.B.; Mercadante, M.A.; Leadbeater, N.E.; Fenteany, G. Access to dienophilic ene-triketone synthons by oxidation of diketones with an oxoammonium salt. Org. Lett. 2012, 14, 498-501. [Abstract] [HTML] [PDF]
Eddy, N.A.; Morse, P.D.; Morton, M.D.; Fenteany, G. Synthesis of oxazolidinone and tosyl enamines by tertiary amine catalysis. Synlett 2011, 5, 699-701. [Abstract] [HTML] [PDF]
Beshir, A.B.; Argueta, C.E.; Menikarachchi, L.C.; Gascón, J.A.; Fenteany, G. Locostatin disrupts association of Raf kinase inhibitor protein with binding proteins by modifying a conserved histidine residue in the ligand-binding pocket. For. Immunopathol. Dis. Therap. 2011, 2, 47-58. [Abstract] [PDF]
Wang, Z.; Castellano, S.; Kinderman, S.S.; Argueta, C.E.; Beshir, A.B.; Fenteany, G.; Kwon, O. Diversity through a branched reaction pathway: generation of a library of sixteen multicyclic scaffolds and identification of antimigratory agents. Chem. Eur. J. 2011, 17, 649-654. [Abstract] [PDF]
Knecht, D.A.; LaFleur, R.; Kahsai, A.W.; Argueta, C.E.; Beshir, A.B.; Fenteany, G. Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics. PLoS ONE 2010, 5, e14039. [Abstract] [HTML] [PDF]
Beshir, A.B.; Ren, G.; Magpusao, A.N.; Barone, L.M.; Yeung, K.C.; Fenteany, G. Raf kinase inhibitor protein suppresses nuclear factor-κB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression. Cancer Lett. 2010, 299, 137-149. [Abstract] [HTML] [PDF]
Magpusao, A.N.; Desmond, R.; Billings, K.J.; Fenteany, G.; Peczuh, M.W. Synthesis and evaluation of antimigratory and antiproliferative activities of lipid-linked [13]-macro-dilactones. Bioorg. Med. Chem. Lett. 2010, 20, 5472-5476. [Abstract] [HTML] [PDF]
Kahsai, A.W.; Zhu, S.; Fenteany, G. G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells. Biochim. Biophys. Acta - Mol. Cell Res. 2010, 1803, 300-310. [Abstract] [HTML] [PDF]
Ménoret, A.; McAleer, J.P.; Ngoi, S.-M.; Ray, S.; Eddy, N.A.; Fenteany, G.; Lee, S.-J.; Rossi, R.J.; Mukherji, B.; Allen, D.L.; Chakraborty, N.G.; Vella, A.T. The oxazolidinone derivative locostatin induces cytokine appeasement. J. Immunol. 2009, 183, 7489-7496. [Abstract] [HTML] [PDF]
Kahsai, A.W.; Cui, J.; Kaniskan, H.Ü.; Garner, P.P.; Fenteany, G. Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site. J. Biol. Chem. 2008, 283, 24534-24545. [Abstract] [HTML] [PDF]
Beshir, A.B.; Guchhait, S.K.; Gascón, J.A.; Fenteany, G. Synthesis and structure-activity relationships of metal-ligand complexes that potently inhibit cell migration. Bioorg. Med. Chem. Lett. 2008, 8, 498-504. [Abstract] [HTML] [PDF]
Mc Henry, K.T.; Montesano, R.; Zhu, S.; Beshir, A.B.; Tang, H.-H.; Yeung, K.C.; Fenteany, G. Raf kinase inhibitor protein positively regulates cell-substratum adhesion while negatively regulating cell-cell adhesion. J. Cell. Biochem. 2008, 103, 972-985. [Abstract] [HTML] [PDF]
Kahsai, A.W.; Zhu, S.; Wardrop, D.J.; Lane, W.S.; Fenteany, G. Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44. Chem. Biol. 2006, 13, 973-983. [Abstract] [HTML] [PDF]
Stossel, T.P.; Fenteany, G.; Hartwig, J.H. Cell surface actin remodeling. J. Cell Sci. 2006, 119, 3261-3264. [Abstract] [HTML] [PDF]
Farooqui, R.; Zhu, S.; Fenteany, G. Glycogen synthase kinase-3 acts upstream of ADP-ribosylation factor 6 and Rac1 to regulate epithelial cell migration. Exp. Cell Res. 2006, 312, 1514-1525. [Abstract] [HTML] [PDF]
Zhu, S.; Mc Henry, K.T.; Lane, W.S.; Fenteany, G. A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration. Chem. Biol. 2005, 12, 981-991. [Abstract] [HTML] [PDF] (This work was highlighted in Chem. Biol. 12, 953-954.)
Farooqui, R.; Fenteany, G. Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement. J. Cell Sci. 2005, 118, 51-63. [Abstract] [HTML] [PDF] (This work was highlighted in J. Cell Sci. 118, 103e and Faculty of 1000)
Altan, Z.M.; Fenteany, G. c-Jun N-terminal kinase regulates lamellipodial protrusion and cell sheet migration during epithelial wound closure by a gene expression-independent mechanism. Biochem. Biophys. Res. Commun. 2004, 322, 56-67. [Abstract] [HTML] [PDF]
Fenteany, G.; Glogauer, M. Cytoskeletal remodeling in leukocyte function. Curr. Opin. Hematol. 2004, 11, 15-24. [Abstract] [HTML] [PDF]
Ankala, S.V.; Fenteany, G. Aryl, alkyl bis-silyl ethers: rapid access to monoprotected aryl alkyl and biaryl ethers. Synlett 2003, 6, 825-828.[PDF]
Fenteany, G.; Zhu, S. Small-molecule inhibitors of actin dynamics and cell motility. Curr. Topics Med. Chem. 2003, 3, 593-616. [Abstract] [PDF]
Mc Henry, K.T.; Ankala, S.V.; Ghosh, A.K.; Fenteany, G. A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. ChemBioChem 2002, 11, 1105-1111. [Abstract] [HTML] [PDF] (This work was highlighted in Trends Biochem. Sci. 27, 605, Drug Discovery Today 8, 6-7 and Faculty of 1000)
Ankala, S.V.; Fenteany, G. Selective deprotection of either aryl or alkyl silyl ethers from aryl, alkyl bis-silyl ethers. Tetrahedron Lett. 2002, 43, 4729-4732. [Abstract] HTML] [PDF]
Fenteany, G.; Janmey, P.A.; Stossel, T.P. Signaling pathways and cell mechanics involved in wound closure by epithelial cell sheets. Curr. Biol. 2000, 10, 831-838. [Abstract] [HTML] [PDF]
Corey, E.J.; Li, W.Z.; Nagamitsu, T.; Fenteany, G. The structural requirements for inhibition of proteasome function by the lactacystin-derived β-lactone and synthetic analogs. Tetrahedron 1999, 55, 3305-3316. [Abstract] [PDF]
Fenteany, G.; Schreiber, S.L. Lactacystin, proteasome function, and cell fate. J. Biol. Chem. 1998, 273, 8545-8548. [HTML] [PDF]
Degnan, B.M.; Degnan, S.M.; Fenteany, G.; Morse, D.E. A Mox homeobox gene in the gastropod mollusc Haliotis rufescens is differentially expressed during larval morphogenesis and metamorphosis. FEBS Lett. 1997, 411, 119-122. [Abstract] [PDF]
Craiu, A.; Gaczynska, M.; Akopian, T.; Gramm, C.F.; Fenteany, G.; Goldberg, A.L.; Rock, K.L. Lactacystin and clasto-lactacystin β-lactone modify multiple proteasome β-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation. J. Biol. Chem. 1997, 272, 13437-13445. [Abstract] [HTML] [ PDF]
Fenteany, G.; Schreiber, S.L. Specific inhibition of the chymotrypsin-like activity of the proteasome induces a bipolar morphology in neuroblastoma cells. Chem. Biol. 1996, 3, 905-912. [Abstract] [PDF]
Fenteany, G.; Standaert, R.F.; Lane, W.S.; Choi, S.; Corey, E.J.; Schreiber, S.L. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 1995, 268, 726-731. [Abstract] [HTML] [PDF]
Fenteany, G.; Standaert, R.F.; Reichard, G.A.; Corey, E.J.; Schreiber, S.L. A β-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc. Natl. Acad. Sci. USA 1994, 91, 3358-3362. [Abstract] [PDF]
Fenteany, G.; Morse, D.E. Specific inhibitors of protein synthesis do not block RNA synthesis or settlement of planktonic larvae in a marine gastropod mollusc (Haliotis rufescens). Biol. Bull. 1993, 184, 6-14. [Abstract] [PDF]